During the Super Bowl last week, CareerBuilder released this commercial:
While this is meant to be a humorous post, it's also completely accurate. You don't want to end up working somewhere that you hate, whether its the people you work with or just the environment in general.
The key thing in any search is to determine what you value in a position. This could be location, salary, flexible hours, travel, or so many different things. If you know this going into your job search, your ability to find a job you will truly enjoy will increase exponentially.
So take the time before you apply to think about what it is you really want. Everyone values different things, just like some people are Coke people and others are Pepsi people. Finding the organization that fits your values is the first step to a long and happy career.